
We believe that unresolved trauma is often at the root of chronic pain, and that cacti point us toward many of the best solutions. By partnering with leading academic hospitals and clinicians, we are devoping better therapeutic approaches for chronic pain that utilize psychedelics, including cactus-derived phenethylamines that are structurally related to mescaline, 2C-B and MDMA.
Most novel investigational new drugs fail clinical trials, in large part due to poorly-predictive animal models. We're using the Blackbox One drug development platform to derisk clinical candidate selection of psychedelic NCEs. Upon completion, our rodent behavioral atlas will automatically detect drug-induced behavioral effects including head twitch response (HTR), anxiety, amphetamine-like hyperlocomotion, somnolence/sedation, pain and analgesia, all from a single group of once-dosed rats.
Untangling the adverse impacts of trauma is essential to healing chronic pain. Our team is collaborating with global leaders in neuropsychology, positive psychology and psychiatry to develop a toolkit for trauma healing that incorporates the latest understanding of the links between unresolved trauma and chronic pain. Our goal is to make sure that veterans, refugees and other groups disproportionately impacted by trauma are first in line for help.
Our scientific team trained under world renowned Harvard neuroscientist, Clifford Woolf, MD, PhD, perhaps best known for his seminal work describing central sensitization of pain. We are exploring which psychedelic assisted therapeutic modalities and molecules are best suited for remapping the sensitized brain circuits that keep patients in chronic pain.
Our CEO, Kaitlin Roberson, is a child advocate and former non-profit director whose professional focus, and Harvard graduate training, is optimizing human development through attention to adverse experiences of childhood that often cause hardship later in life.
Our team is using AI behavioral modeling to look at the benefits of mescaline and other cactus-derived medicinal compounds in treating migraine and cluster headache. We are also collaborating with global leaders in migraine science to explore clinical trials of mescaline, psilocybin and MDMA for treatment of cluster headache and related chronic headache conditions.